D-dimer Protein (Native)

Catalog# BNP1012

Lot # Check on the product label

Size 100 μg

Description

Native human D-dimer protein.

Source Human plasma

Formulation Liquid

Purification 

lon exchange chromatography

Purity >85% by SDS-PAGE

Application

ELISA

Other applications have not been tested.

Storage buffer

0.01 M PBS, 10mM Tris,QM08 Protein stabilizer, 0.1% Proclin300.

Storage & Expiration

Ship at 4℃. Upon receipt, aliquot and store at 2-8℃ for long term.

Avoid repeated freeze and thaw cycles.

Background

D-dimer is a fibrin degradation product (or FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it contains two crosslinked D fragments of the fibrin protein. The D-dimer antigen is a unique marker of fibrin degradation that is formed by the sequential action of 3 enzymes: thrombin, factor XIIIa, and plasmin. Its concentration may be determined by a blood test to help diagnose thrombosis. Since its introduction in the 1990s, it has become an important test performed in patients suspected of thrombotic disorders. While a negative result practically rules out thrombosis, a positive result can indicate thrombosis but does not rule out other potential causes. Its main use, therefore, is to exclude thromboembolic disease where the probability is low. In addition, it is used in the diagnosis of the blood disorder disseminated intravascular coagulation.

Reference

1. Adam SS, Key NS, Greenberg CS (March 2009). "D-dimer antigen: current concepts and future prospects". Blood 113 (13): 2878–2887.