Prostate Specific Antigen, PSA Protein (Active)

Catalog# BNP1025

Lot # Check on the product label

Size 0.1 mg

Description

Purified human PSA protein.

Synonyms Prostate specific antigen, PSA, gamma-seminoprotein, Seminin, Kallikrein-3, P30 antigen, Semenogelase, KLK3, APS

Source Human seminal fluid

Formulation Liquid

Concentration 2 mg/ml

Purity >90% by SDS-PAGE

Application

ELISA

Other applications have not been tested.

Storage buffer

Each vial contains 0.01 M PBS, 0.15 M NaCl (pH 7.4) without preservative.

Storage & Expiration

Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term.

Avoid repeated freeze and thaw cycles.

Background

Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is an androgen-regulated serine protease produced by both prostate epithelial cells and prostate cancer (PCa) and is the most commonly used serum marker for cancer. It is a member of the tissue kallikrein family, some of the members of which are also prostate specific. PSA is a major protein in semen, where its function is to cleave semenogelins in the seminal coagulum. PSA is secreted into prostatic ducts as an inactive 244-amino acid proenzyme (proPSA) that is activated by cleavage of seven N-terminal amino acids. Measurement of free versus total PSA can increase specificity for PCa. PSA is also widely used to monitor responses to therapy and is under investigation as a therapeutic target.

Reference

1. Balk SP, Ko YJ, Bubley GJ (January 2003). "Biology of prostate-specific antigen". J. Clin. Oncol. 21 (2): 383–91.