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Catalog# |
BRP1186-2 |
|---|---|
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Lot # |
Check on the product label |
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Size |
50 μg |
|
Description |
Recombinant human IL-15 is produced by the E.coli system, with the target gene encoding Asn49-Ser162 expressed. |
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Synonyms |
IL15, IL-15, interleukin 15 |
|
Source |
E.coli |
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Uniprot No. |
P40933 |
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Purity |
>95% by SDS-PAGE |
|
Endotoxin level |
<0.01 EU/µg by LAL test |
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Formulation |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 4%Mannitol, pH 7.0. |
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Reconstitution |
Dissolve the lyophilized protein in distilled water (It is not recommended to reconstitute to a concentration <100 μg/ml.) |
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Application |
SDS-PAGE Other applications have not been tested. The optimal dilutions should be determined by end user. |
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Storage& Expiration |
Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles. |
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Background |
Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2 (IL-2). Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces the proliferation of natural killer cells, i.e. cells of the innate immune system whose principal role is to kill virally infected cells. |
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Reference |
1. Steel JC, Waldmann TA, Morris JC (January 2012). "Interleukin-15 biology and its therapeutic implications in cancer". Trends Pharmacol Sci. 2. Di Sabatino A, Calarota SA, Vidali F, Macdonald TT, Corazza GR (February 2011). "Role of IL-15 in immune-mediated and infectious diseases". Cytokine & Growth Factor Reviews. 22 (1): 19–33. |
