Monoclonal Anti- Doxycycline antibody

Catalog# BDA1017

Lot # Check on the product label

Size 1mg

Host Mouse

Product Form Liquid

Concentration 7mg/ml (Changed for different lots)

Purification & Buffer

Protein A or G purified and supplied in 0.01 M PBS (pH7.4)

Purity >95% by HPLC & SDS-PAGE

IC50 Value

0.6-1.0 ppb

Sensitivity 0.1 ppb

Recommend Application

ELISA (1:100000)

Other applications have not been tested.

The optimal dilutions should be determined by end user.

Storage Instruction 

Aliquot and store at -20°C for 2 years.

Avoid repeated freeze and thaw cycles.

Background

Doxycycline is a medication useful for the treatment of a number of types of infections by bacteria and protozoa. It is useful for bacterial pneumonia, acne, chlamydia infections, Clostridium difficile colitis, early Lyme disease, cholera and syphilis. It is also useful for the treatment of malaria when used with quinine and for the prevention of malaria. Doxycycline can be used either by mouth or intravenously. Agbedanu PN et al study revealed that doxycycline was effective at inhibiting the efflux of ivermectin and doramectin (minocycline had no effect). These two avermectins, in combination with doxycycline, should be considered when treating meningeal worms in alpacas. Biofilm formation on dental abutment may lead to peri-implant mucositis and subsequent peri-implantitis. These cases are clinically treated with antibiotics such as doxycycline (Doxy). An abutment surface coated with Doxy has potential for preventing bacterial colonization when exposed to the oral cavity. Doxy-coating could be a viable way to control peri-implant mucositis and prevent its progression into peri-implantitis.

Reference

1. "Doxycycline calsium". The American Society of Health-System Pharmacists. Retrieved Aug 18, 2015.

2. Agbedanu PN, Anderson KL, Brewer MT, Carlson SA. Doxycycline as an inhibitor of p-glycoprotein in the alpaca for the purpose of maintaining avermectins in the CNS during treatment for parelaphostrongylosis. Vet Parasitol. 2015 Sep 7.

3. Xing R, Witsø IL, Jugowiec D, Tiainen H, Shabestari M, Lyngstadaas SP, Lönn-Stensrud J, Haugen HJ. Antibacterial effect of doxycycline-coated dental abutment surfaces. Biomed Mater. 2015 Sep 11;10(5):055003.